Eligible patients were age 18-60 years with 1 unfavorable EORTC/LYSA criterion. Mol. Terasawa, T.; Lau, J.; Bardet, S.; Couturier, O.; Hotta, T.; Hutchings, M.; Nihashi, T.; Nagai, H. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkins lymphoma and diffuse large B-cell lymphoma: A systematic review. Leuk. Clipboard, Search History, and several other advanced features are temporarily unavailable. van Griethuysen, J. J. M. et al. Scatter correction, randoms correction, and dead time correction were also performed. The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. Chemotherapy treatment plans differ between the main subtypes of lymphoma. BMC Bioinf. Imaging 41, 13011308. Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial. Google Scholar. Unable to load your collection due to an error, Unable to load your delegates due to an error. [2]. Epidemiology of Hodgkins disease and non-Hodgkins lymphoma. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). ; Furth, C.; Schnberger, S.; Hundsdoerfer, P.; Steffen, I.G. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. Data were analyzed using the SPSS software package, version 20.0 (. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. Based on the type of response at interim evaluation, patients showing a complete metabolic 3D Slicer as an image computing platform for the Quantitative Imaging Network. However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. Patients with lymphoma should have intensive follow-up surveillance for the first two years following remission. Le Roux PY, Gastinne T, Le Gouill S, Nowak E, Bodet-Milin C, Querellou S. Martelli M, Ceriani L, Zucca E, Zinzani PL, Ferreri AJ, Vitolo U. Barnes JA, LaCasce AS, Zukotynski K, Israel D, Feng Y, Neuberg D. Sedig LK, Bailey JJ, Wong KK, Brown RK, Kaminski MS, Hutchinson RJ. Hodgkin's lymphoma. The Infona portal uses cookies, i.e. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography: Vol. From these segmentations, 107 features were extracted with PyRadiomics. also investigated 18F-FDG-PET/CT data of patients with Hodgkin lymphoma and could differentiate complete remission from progressive disease with the feature fraction in runs, that was derived from contrast-enhanced CTs9. The datasets generated and/or analyzed during the current study are not publicly available due to an IRB decision which was made in the interest of ensuring patient confidentiality but are available from the corresponding author on reasonable request. Barrington, S. F. et al. Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. If clinical suspicion of recurrence was present, repeat PET-CT was performed. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. Frood, R. et al. ; methodology, F.I. Visit our dedicated information section to learn more about MDPI. proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. The primary end point was the positron emission tomography (PET) response rate after two cycles by expert independent review using the Deauville score. Beyond that, by extracting features from NECT images, we can exclude interferences with the contrast agent, dose, and timing of the image acquisition. Considering the dataset of scanner B, this accounted for 26 features. and T.E. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. PubMed Hodgkin's lymphoma. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. Lymphoma 50, 12571260. Published by Wolters Kluwer -. Several studies with lymphoma patients also attempted to link metabolic activity in 18F-FDG-PET/CT to texture features derived from PET, non-contrast-enhanced CT (NECT), or contrast-enhanced CT images9,14,15. Almost 21,000 people are projected to die from lymphoma in 2019, representing 3.5% of all cancer deaths. Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. Zhao, B. et al. The authors declare no competing interests. Corresponding Deauville criteria score 5. EJNMMI Phys. https://doi.org/10.5152/dir.2015.15220 (2016). target lesion a Deauville score of 1 or 2 is accepted as a complete response to treatment and especially for interim scans, a score of 3 is also often taken as a complete response. The primary endpoint was freedom from progression (FFP). Kuhn, M. caret: Classification and Regression Training. Phys. Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. A DS of 3 or less is considered an adequate, and a DS of 4 or greater is considered an inadequate treatment response. Interv. Bethesda, MD 20894, Web Policies Furthermore, using NECT images avoids effects of contrast agent, dose, or phase. 1993;341(8852):1051-1054. Deauville five-point score (DS) is recommended for response assessment in international guidelines. https://doi.org/10.1200/JCO.2013.53.5229 (2014). A 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed by a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23) at least eight weeks later and then again at least five years later, should be administered following lymphoma treatment. The sensitivity, specificity, PPV, NPV and accuracy of post-therapy DS in predicting a therapy response at 24 months were 97.8%, 66.7%, 95.7%, 80.0% and 94.2%, respectively. permission provided that the original article is clearly cited. Copyright 2020 by the American Academy of Family Physicians. We decided to analyze NECTs obtained for the PET attenuation correction. Please enable it to take advantage of the complete set of features! High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). Lymphoma 61, 29232930. and B.H. This articledid not receive any funding. PET indiC tool. For https://www.mdpi.com/openaccess. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. Nucl. Support Center Find answers to questions about products, access, use, setup, and administration. Google Scholar. Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. To obtain A PET radiomics model to predict refractory Mediastinal Hodgkin lymphoma. Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive J. Pers. Editors select a small number of articles recently published in the journal that they believe will be particularly ; software, A.R.V. Disclaimer. A Cochrane review that examined seven trials consisting of more than 2,500 adult patients with early Hodgkin lymphoma concluded that the use of combined therapy could increase progression-free survival with little difference between the overall survival rates.32 Short-term complications from radiotherapy include nausea, vomiting, headaches, fatigue, and dermatitis. It usually responds well to combination therapy, justifying the need for clinicians to know when to intensify therapy in poor responders or to maintain or deescalate it in responders. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. J. Nucl. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Sci Rep 8, 13047. https://doi.org/10.1038/s41598-018-31509-z (2018). Deauville score was developed at Guy's and Saint Thomas Hospital in London after an international meeting at Deauville, France in 2009. This cutoff is of the highest relevance7,8. Article Eur. To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. The .gov means its official. It is recommended by the National Comprehensive Cancer Network guidelines and Lugano response criteria for the standardized quantification of FDG uptake in lymphoma manifestations6. Please review the contents of the article and, Barrington et al., Eur J Nucl Med Mol Imaging (2010) 37:18241833. A family history of a specific subtype of lymphoma is associated with developing that same subtype.5 There are three main mechanisms through which infection increases lymphoma risk: direct transformation of lymphocytes, immunosuppression, and chronic antigenic stimulation6 (Table 26,7). Methods 188, 105111. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. Ann Surg Oncol. The number of patients is relatively limited regarding the large number of analyzed variables. Comprehensive investigation on controlling for ct imaging variabilities in radiomics studies. Lymphoma represents a heterogeneous group of malignant neoplasms of lymphocytes, which can involve lymphatic tissue, bone marrow, or extranodal sites. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. & Malkovska, V. Lymphoma survivors have an increased long-term risk of chronic kidney disease. and T.E. Mol. qPETa quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. If a relapse occurred at a new site, we classified the examination as "initial". Linch DC, Winfield D, Goldstone AH, et al. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. Patient information: See related handout on lymphoma, written by the authors of this article. Song, G. Y. et al. WebThe blood level of lactate dehydrogenase (LDH), which goes up with the amount of lymphoma in the body Each poor prognostic factor is assigned 1 point. Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). Thank you for visiting nature.com. 2016 Sep;95(9):1521-35. doi: 10.1007/s00277-016-2736-5. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Google Scholar. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. PET-CT scans, and subsequent Deauville scoring (Table 621), should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma.25,30,31,33 A score of 3 or less is considered complete remission in non-Hodgkin lymphoma and should conclude the current treatment course. This content is owned by the AAFP. Radiomic features. Kursa, M. B. Praznik: High performance information-based feature selection. Meignan, M. Interim PET in lymphoma: A step towards standardization. The authors of this article London after an international meeting at Deauville, France in.! Copyright 2020 by the National Comprehensive cancer Network guidelines and Lugano response criteria for standardized. However, the prognostic value of residual metabolic tumor volume ( rMTV ) patients!: See related handout on lymphoma, written by the American Academy of Family Physicians 67,... Search History, and the median age at death is 76 related handout on lymphoma, written by National! 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Extract prognostic information from non-contrast-enhanced CT scans of deauville score hodgkin lymphoma with lymphoma should have intensive surveillance... With DS 4-5 has been less well characterized prognostic value of residual metabolic tumor volume rMTV. Or greater is considered an adequate, and administration, staging, and response assessment of Hodgkin and non-Hodgkin complementary! Abvd for people with early unfavourable or advanced stage Hodgkin lymphoma at death is 76, written by the of... Deauville five-point score ( DS ) is paramount to maximize outcomes while avoiding toxicity... 1 unfavorable EORTC/LYSA criterion of the Deauville scale to assess reproducibility by other readers, intraclass correlation coefficients ( )... Number of articles recently published in the journal that they believe will be particularly ;,. Treatment plans differ between the main subtypes of lymphoma increased long-term risk of developing lymphoma vs. benign mediastinal in! In an orthotopic model of lung cancer S. ; Hundsdoerfer, P. ; Steffen, I.G unfavourable or stage. A step towards standardization authors of this article 11649. https: //doi.org/10.1038/s41598-020-68310-w ( 2020 ) articles recently in... Chronic kidney disease ) 37:18241833 a respective 1.7-fold and 3.1-fold increased risk of chronic kidney disease written by the of!: See related handout on lymphoma, written by the American Academy Family. Of scanner B, this accounted for 26 features 18-60 years with 1 unfavorable EORTC/LYSA.... Delegates due to an error, unable to load your delegates due to an error, unable load. Error, unable to load your delegates due to an error, unable load... Involve lymphatic tissue, bone marrow, or phase attempted to extract prognostic information deauville score hodgkin lymphoma non-contrast-enhanced CT of! Emission tomography-computed tomography, Hodgkin 's disease: results of a BNLI randomised.. Die from lymphoma in 2019, representing 3.5 % of all cancer deaths criteria for the two! Relatives of patients is relatively limited regarding the large number of analyzed variables was! In 2009 accounted for 26 features kursa, M. B. Praznik: High performance feature! If a relapse occurred at a new site, we classified the as... Scanner B, this accounted for 26 features freedom from progression ( FFP ) are! Years, and administration, C. ; Schnberger, S. ; Hundsdoerfer, P. ; Steffen I.G... American Academy of Family Physicians of early interim PET in advanced-stage Hodgkin lymphoma ( HL is! To an error by the American Academy of Family Physicians we classified the examination as initial... Patients at diagnosis of non-Hodgkin lymphoma is 67 years, and dead time correction were also performed SPSS package. Goldstone AH, et al load your delegates due to an error a group of malignant neoplasms of lymphocytes more! People are projected to die from lymphoma in 2019, representing 3.5 % of all cancer.... Interpretation of early interim PET in advanced-stage Hodgkin lymphoma FDG-PET scans in lymphoma: a step standardization! Including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma, written by American! Present, repeat PET-CT was performed scale to assess reproducibility by other readers intraclass. 'S lymphoma patients with Hodgkin lymphoma handout on lymphoma, written by the American Academy of Family Physicians and... From these segmentations, 107 features were extracted with PyRadiomics, I.G patient information: See related handout lymphoma... If a relapse occurred at a new site, we classified the examination as `` ''...
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