Another descendent of the Siamese cat, these short haired cats dont tend to shed much which gets them on the list of those breeds that are more hypoallergenic than others. Then you pet the cat or bring out the brush, and the cycle begins anew. Credit: New Africa / Adobe Stock. In conclusion, we observed cat-to-cat variability of Fel d 1 levels in fur of domestic cats unrelated to breed, sex, or age. Russian Blue cats are another very intelligent breed, so its important to provide enough mental and physical stimulation to keep them happy. 1996;64(7-8):505-14. This website uses cookies to improve your experience. Results: The study included 26 cats, 13 male, 13 female, age 5.6 4.3 years (mean SD). It is often mistaken that peoples allergies to cats are triggered by cats fur. Also Siamese release a very low level of dander which is also the main reason for many allergic reactions. Methods 2009;64(10):1498-506. Fel d1 levels were measured using a commercially available Fel d1 ELISA kit (Indoor Biotechnologies, USA). PMC Each allergen in a species is given a number when it is identified. Despite their stern expression, Sphynx cats are energetic and often goofy tricksters. Fel d1 is a major allergen that may affect humans sensitive to cat allergens, and it can be detected in the saliva and on the hair of cats. These results indicate that salivary samples taken at a single point are not ideal for estimation of the cats average Fel d1 level and biological variability of Fel d1 should be taken into account in future studies. For exercise, make sure your cat has a scratching post for some necessary stretching. A kitten's allergen level is an inherited trait. Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. Slow lorises are one of only a few venomous mammals and the only known venomous primate. They dont have any special exercise needs and unlike many other cat breeds they like water so watch out if youre having a bath. However, Sphynx cats still require regular maintenance, especially are their large ears. eCollection 2021 May 20. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Similar to the Balinese, the Siberian is covered by a long coat, but still considered hypoallergenic because they produce fewer Fel D1 in their saliva. The Peterbald cat is a strange little fellow. A Novel Approach to the Reduction of Cat Allergen Fel d1 Through Inclusion. Airborne concentrations and particle size distribution of allergen derived from domestic cats (. [7] Several other breeds are widely referenced as causing a diminished immune reaction in cat allergy sufferers, including Sphynx, Russian Blue, Cornish Rex, Devon Rex, Siamese, Javanese, Oriental shorthair, Burmese, and Laperm. Arroyo AC, Robinson LB, Geller RJ, Rudders SA, Sullivan AF, Hasegawa K, Camargo CA Jr. J Allergy Clin Immunol Pract. There are many misconceptions and conflicting reports related to cat allergens,20 including the propensity of specific cat breeds to secrete lower levels of Fel d1, and hair colour or length and gender being associated with Fel d1 levels.21-24 Hence, one of the first questions Bastien et al.25 sought to answer in the study presented in this poster was whether specific factors such as age, weight, and breed had any effect on the levels of Fel d1 secreted in feline saliva. View the infographic below and read on to learn more about 8 cat breeds to consider adopting if you have allergies. 5. It was discovered that, by Week 3, cats receiving the ingredient containing anti-Fel d1 IgY in their diet had an approximately 24% reduction in their salivary aFel d1 levels in comparison to baseline. Animal allergens and their presence in the environment. A minimum of three tests must be perfomed for each cat for the results to be considered reasonably accurate in adult cats. Commercially available ELISA kits were used to measure Fel d1 and Fel d4. Immun Inflamm Dis. Kamal MA, Dingman R, Wang CQ, Lai CH, Rajadhyaksha M, DeVeaux M, Orengo JM, Radin A, Davis JD. Accessibility J Allergy Clin Immunol Pract. Mammalian-derived respiratory allergens - implications for diagnosis and therapy of individuals allergic to furry animals. Human hair: an unexpected source of cat allergen exposure. These felines are intelligent, active, and require regular stimulation. Siamese cats are often labeled as dog-like because they enjoy following their humans around and enjoy playtime, like fetch, so stock up onactive cat toys. To weaken the amount of Fel D1 exposure these cats emit, we recommend regular bathing and brushing of feline companions. Theyre laid-back but enjoy playing, and are very attached to their humans. Human allergy to cats: A review for veterinarians on prevalence, causes, symptoms and control. As such, allergic reactions to a particular cat may be better or worse when compared to other breeds. Black Sphinx Cat Regardless of color, the Sphinx cat is among the most renowned in the hairless cat world. This one may surprise you. Enter multiple addresses on separate lines or separate them with commas. Epub 2021 Oct 8. Fel D1: The majority of cat allergies are caused by a small stable glycoprotein called Fel d1. So if you are after an independent and introverted type of kitty this isnt the breed for you. This cat breeds that are hypoallergenic post contains affiliate links. Heinzerling L et al. We can Identify them. Studies have shown that this single allergen, which belongs to the uteroglobin protein family, is at least as good as cat dander extract in identifying cat-allergic patients. Mammalian lipocalin allergensinsights into their enigmatic allergenicity. J Feline Med Surg. A large percentage of people with cat allergies are reacting to the presence of the Fel d 1 Protein. As they shed so little they put out less of the Fel D1 protein. This affectionate cat is a charming and loyal pet who loves people. These cats all produce very low levels of Fel d1, and they don't shed very much. And, yes, it is true that Siberian cats don't have much of that allergen. They require a little bit more cat care than other breeds because they need to be bathed weekly in order to keep their coats from getting oily and attracting dirt. Variability in Fel d1 in cats is unrelated to cat phenotype but decreases with age. Cats are the best. However, 20% of the sampling of Siberian cats produce a very low level of Fel d1, so . Sex Differences in Mouse Exploratory Behaviour to Fel d 1, a Cat ABP-Like Protein. Clin Exp Allergy. Moreover, cats with a lower average Fel d1 had lower variability over the year compared to cats with higher average Fel d1 levels. [Major feline antigen--Fel d I clinical aspects]. However, the most clinically relevant of these data showed an improvement in nasal and some ocular symptoms in individuals sensitised to Fel d1 with this approach. The authors also observed improvement in other allergic symptoms such as nasal itching, sneezing, and runny nose; however, the reduction in these scores was not statistically significant. It is often mistaken that peoples allergies to cats are triggered by cats fur. Although females and neutered males produce Fel d 1 in lower levels, they still produce enough to cause allergic symptoms in sensitive individuals. Grnlund H et al. and N.S. [1], Proteins matching the InterPro family signature for Fel d 1 parts is widespread among Theria, a subclass of mammals[8] amongst the Theriiformes (the sister taxon to Yinotheria.) Where does cat allergen 1 come from? Cat is, Both the normal and mutant copies of the Fel d1 gene detected. This cats gets along well both with humans and . With emerald-green eyes and a luxurious silvery coat, Russian Blues are a startlingly pretty breed. When the Cornish Rex breed does have fur it tends to be curly and sit close to their skin and this means that this breed sheds less than others. When cats lick their fur clean, the protein dries up, and becomes an airborne allergen. A very unusual and pricey cat breed is the regal Sphynx. 2018. Javanese cats are intelligent, boasting exceptional communication skills. When these tests were repeated, they were always inconsistent and have been removed from the following tables. Following a control diet period of 1 week, the cats were split into two groups: one to continue with the control diet, and the other to receive the control diet supplemented with an egg product ingredient containing anti-Fel d1 IgY antibodies, for 4 weeks. Satyaraj E et al. Here is the place to post pictures, ask questions, and hopefully even network with breeders or rescue groups for the incredible Siberian Cat! Yang WH, Kelly S, Haya L, Mehri R, Ramesh D, DeVeaux M, Wang CQ, Meier P, Narula S, Shawki F, Pennington R, Perlee L, O'Brien MP. It was next investigated if either anti-Fel d1 antibodies could attenuate the Fel d1-mediated activation of IgE and the subsequent allergic cascade, measured through the release of beta-hexosaminidase in humanised rat basophilic leukaemia cells. Substantial reductions in aFel d1 levels were observed from Week 3 onwards (p<0.001), and on average the reduction in aFel d1 levels was 47% by Week 10 (Figure 2A). Design Saliva samples were collected weekly and Fel d1 levels therein were estimated using commercially available direct ELISA (Indoor Biotechnologies, USA). The protein is responsible for the array of symptoms that accompany a cat allergy, such as sneezing, coughing, fever, and more. However, to keep its allergen levels low, its still suggested that you groom them regularly. Medians and ranges were calculated. The methodology and results of these studies have recently been published in a peer-reviewed article.26. They are a cross of Siamese cats and the American short hair breeds. Fel d 1 and Fel d 4 were eluted, 3 aliquots from each sample were analyzed by means of ELISA, and the average was reported (Indoor Biotechnologies, Charlottesville, Va). Fairly reliable tests for their Fel d 1 protein production is available for individual cats, but research regarding entire breeds continues, hampered by the lack of a thoroughly accessible and accurate genetic test for production of the antigen. Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes.[2][3]. Conversely, Fel d4 was higher than Fel d1 in saliva (7.62, 1.32-18.5 vs. 2.45, 0.75-5.73 ug/ml, respectively, p=0.039). About 50% of Siberians were found to have lower Fel d1 levels than normal cats. Under 15% of Siberians produced verylow levels of the allergen, and could safelybe placed in homeswithsevere or dangerous reactions tocats. Low allergen matings produced more offspring with reduced lower levels of Fel-d1, though some kittens from most low-allergen matings still had normal levels of Fel d1. There is still considerable difference of opinion on this subject. Further research will be required to demonstrate the usefulness of this approach for managing cat allergens in the home. Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. This breed has a delightful personalityoutgoing, affectionate, friendly, and energeticmaking it an exceptional feline companion. European Respiratory Society442 Glossop RoadSheffield S10 2PXUnited KingdomTel: +44 114 2672860Email: journals@ersnet.org, Print ISSN: 0903-1936 These include Fel d 1 hypoallergens and allergen constructs where Fel d 1 is coupled to immunomodulatory proteins or carriers. Across the board, around 50% of Siberian cats produce less Fel d1 allergenic proteins than the average for moggies and pedigree cats of other breeds, whilst 20% of cats of the breed are considered to produce very low levels of it - to the point that cats in this group might not trigger allergies at all in some allergy sufferers. With this study, it was demonstrated that humans with feline allergies had substantial improvement in their TNSS scores and some ocular scores when exposed to bedding from cats fed a diet with an egg product ingredient containing anti-Fel d1 IgY as compared to bedding from control diet-fed cats. Dhami S, Agarwal A. Image, Download Hi-res Many people believe that the breed produces less Fel d1, the primary allergen present on cats. The .gov means its official. KittenTesting.com funded studies using citric acid with Siberians, and found it directly interfered with Fel d1 tests. and transmitted securely. In 1999 Indoor Biotechnologies tested the fur of four cats for Fel d 1; a mixed breed, two Siberians, and an Abyssinian. There was an 80-fold difference in Fel d1 levels between the highest and lowest Fel d1-producing cats. The approaches have been evaluated in experimental in vitro and in vivo model systems with promising results. Before any allergy sufferer gets their hopes high, it should be noted that hypoallergenic doesnt mean non-allergenic. Add to this their thick tail that often finishes in a black tapered tip and you have one seriously cute cat. Epub 2020 Dec 24. Purina Institute. HHS Vulnerability Disclosure, Help Before use of anticholinergic medication and after anesthesia, 0.25 to 0.50mL of saliva was pipetted from the cheek pouches. 2021 Nov 4;11(11):3149. doi: 10.3390/ani11113149. Recently, Fel d 1 and Fel d 4specific IgE was assessed in patients with petallergy. 2021 Nov 4;11(11):3149. doi: 10.3390/ani11113149. This is an extroverted and bright cat breed that is great for kids and families. 12-15 years. The authors next aimed to ascertain if these in vitro results could be translated in an animal model. 1974;113(6):1668-77. van Ree R et al. 1992;69(4):321-2. Find out more on the about page. Both chains share an all alpha-helical structure. Thus, 105 domestic shorthair cats were enrolled, aged 7 months to 17 years, of either gender, and neutered or intact, in a 2-week baseline period on a control diet followed by separation into two groups. Peterbald cats love attention and are very active cats in general, as well as being very loyal and loving. The authors next sought to examine whether these observations could be replicated using anti-Fel d1 IgY antibodies isolated from egg yolks instead of the polyclonal anti-Fel d1 antibodies. The Minskin breed was created from the Sphynx cat breed. On this Wikipedia the language links are at the top of the page across from the article title. Health They dont like being alone and do get bored easily so a sibling is often a good idea. You would love to have one around. However, if you or someone in your home is extremely sensitive to cats they may have some issues so it is always best to check with a breeder for their advice before bringing one of these felines into your home. But they dont tend to lose that down the way that other breeds shed. These proteins can be found in anything from dander, saliva, urine and other substances the cat produces. Cat allergen exposure in a naturalistic exposure chamber: Aprospective observational study in cat-allergic subjects. FOIA With hairless, grey-silver skin, a slanted face, and large pointy ears, this Russian cat breed has certainly earned its place on this list. Unable to load your collection due to an error, Unable to load your delegates due to an error. The mischievous Devon Rex cat, also known as the pixie cat, is a loving and loyal feline breed. Theria includes the eutherians that includes the placental mammals and the metatherians that includes the marsupials. Hello, kitty: could cat allergy be a form of intoxication? During a landmark Purina study, 97% of cats fed LiveClear cat food showed decreased levels of active Fel d 1 on their hair and dander, starting in the 3rd week of feeding. Fur Fel d 1 and Fel d 4 levels show no relation to hair length on a per-gram basis, https://doi.org/10.1016/j.jaci.2018.07.033, Fel d 1 and Fel d 4 levels in cat fur, saliva, and urine, View Large They love to help out and enjoy following and often supervising their favourite humans. This article was funded by the Purina Institute and reviews data presented at the European Academy of Allergy and Clinical Immunology (EAACI) Congress held on 1st5th June in Lisbon, Portugal. 2005;60(10):1287-300. For those suffering from a cat allergy, yet still long to have a feline companion, some hypoallergenic cat breeds might be worth considering. An estimated 10% of people have an allergy to cats or other pets. Please enable it to take advantage of the complete set of features! Due to biological interactions, it not suitable for testing Fel d-1. All rights reserved. Influence of time and phenotype on salivary Fel d1 in domestic shorthair cats. Overall TNSS score and the subscore for nasal congestion were substantially reduced in subjects exposed to hair from cats fed the test diet in comparison to the priming exposure (p=0.0350 and p=0.0055, respectively). Chapter 1: Fel d 1, the major cat allergen. Siberian naturally produces little of the allergenic protein FEL D1, responsible for allergies for 85% of people allergic to cats. In vivo and in vitro diagnostics of cat allergy is currently based on cat dander extract. If youre bored, theyll help you lighten up and feel energized. Results using Drontal and Citric Acid to induce saliva were highly irregular and discarded from the study. Six of the 15 on this list are Siamese breeds, showing that this is a good breed from which to start your search. Pilot study to determine the effect of feeding cat food made with egg product containing anti-Fel d1 antibodies to cats on human allergy symptoms. Similar to the Siamese, its sweet and highly social. 2010;151(4):265-74. doi: 10.1590/1678-9199-JVATITD-2020-0051. All allergen charts on the Kitten Testing website are protected by copyright. The breed was generated from a mix of the Sphynx, Munchkin and American Curl breeds. Cat is. Influence of time and phenotype on salivary Fel d 1 in domestic shorthair cats. The popular Siamese cat breed will shed minimally if you brush your kitty regularly. official website and that any information you provide is encrypted More advanced testing has been created by Kitten Testing. It also produces low levels of Fel D1 protein, which means that its long gorgeous coat will not generate an allergic reaction. 15, 16, 20 Bastien et al 16 observed an 80-fold An official website of the United States government. Reduction of active Fel d1 from cats using an antiFel d1 egg IgY antibody. 2005 Jun;137(2):141-4. doi: 10.1159/000085793. In tests of hundreds of cats, Indoor Biotechnologies found levels ranging from just 5. Featured Image Credit: Veera, Shutterstock They make a great lap warmer in the wintertime. 2021 May;9(5):2126-2128.e3. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides. However, Fel d1 is created in the perianal glands, skin, saliva, and tears. Maine Coon Cats About 50% of Siberians were found to have lower Fel d1 levels than normal cats. Figure 1: Chimeric ELISA comparison of IgY antibodies isolated from eggs produced by Fel d1-immunised (anti-Fel d1 IgY) hens compared to IgY from the same hens prior to immunisation (pre-immune IgY). Dr Satyaraj is an employee of Nestl Purina Petcare, St. Louis, Missouri, USA. Whilst they can appear delicate, they are actually quite muscular and love to jump and climb. Devon Rex cats are jumpers, and their favorite place is at head level, so perches and cat trees should be provided. Once you have your cat home there are several things that you can do to reduce the effect of any allergic reactions. Since monoclonal anti-Fel d1 antibodies could not produce the same effect, it can be concluded that multiple epitopes of Fel d1 must be blocked to prevent its binding to IgE and initiation of the IgE-mediated allergic response cascade. 2014;146(5):1347-57. The Russian Blue is nearly hypoallergenic. We do not capture any email address. Disclaimer. 2021 May 20;11(3):46-60. doi: 10.5662/wjm.v11.i3.46. Grau C, Bienboire-Frosini C, Arroub S, Lafont-Lecuelle C, Leclercq J, Pageat P. Animals (Basel). Theyre known for theirunique look, too: satellite-dish ears, mischievous eyes, and an overall ethereal appearance. DOI: https://doi.org/10.1016/j.jaci.2018.07.033, Red Maple Trials, Ottawa, Ontario, Canada, Merivale Cat Hospital, Ottawa, Ontario, Canada. The Balinese cat is similar to the Russian Blue when it comes to hypoallergenic tendencies. MeSH Federal government websites often end in .gov or .mil. Balinese. Similar to the Siamese, the breed is a curious, playful and chatty . Crystallographic structure of the Fel d 1 dimer, the primary, This article incorporates text from the public domain, InterPro taxonomy view, IPR006178 and IPR015332, "The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family", "Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning", "Polymorphism Analysis of Ch1 and Ch2 Genes in the Siberian Cat", "Allergy to Cats - Cat DNA Test Kit | Basepaws", "Another cat and mouse game: Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches", "Mad, bad and dangerous to know: the biochemistry, ecology and evolution of slow loris venom", "An update on molecular cat allergens: Fel d 1 and what else? With these data, it can be concluded that Fel d1-specific IgY antibodies bind Fel d1 in cat saliva, thereby blocking the ability of the latter to bind IgE and induce IgE-mediated degranulation. The eyes of the Cornish Rex cat tend to be golden in colour although that can vary. Jalil-Colome J et al. Careers. This short-haired cat breed sheds less frequently than other cat breeds and requires less grooming maintenance from their owners as well as emitting less Fel D1. and transmitted securely. On exposure in sensitised individuals, the unbound form of Fel d1, termed active Fel d1 (aFel d1) in this report, binds IgE and leads to mast cell degranulation, thus initiating the allergic response cascade. It was observed that there was no association between salivary Fel d1 levels and factors such as bodyweight, body condition score, and the colour and pattern of the hair. Clin Transl Sci. Chapter 1: Fel d 1, the major cat allergen", https://en.wikipedia.org/w/index.php?title=Fel_d_1&oldid=1115663621, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 12 October 2022, at 15:34. All cats produce some amount of Fel d1, but that doesn't mean that all cats are equally allergenic. Curr Opin Allergy Clin Immunol. The first house cat allergen identified was labeled Feline domesticus allergen 1, or (Fel d 1). These antibodies are transferred to the egg where they provide passive immunity to the hatchlings. The ISO 9001 standard is an internationally recognised standard that is based on a number of quality management principles including a strong customer focus, the management of process change, effective methods of reducing non- compliance, and the continual improvement in the quality of our services. Its an ancient breed thought to be ancestral to all modern long-haired cats. Furthermore, the data suggest that saliva is the main source of Fel d 4. 2022 Jan;24(1):31-42. doi: 10.1177/1098612X211036793. Like Siberians, Russian Blue Cats have lower levels of Fel D1 protein than other cat breeds. In fur, Fel d4 (0.09, 0.03-0.19 ug/g) was much lower than Fel d1 (12.24, 5.0-25.0 ug/g), (p<0.001). This wont affect the price you pay. A specific and dose-dependent reduction in beta-hexosaminidase release was discovered when the polyclonal, but not monoclonal, anti-Fel d1 antibodies were incubated with cat saliva samples. Epub 2013 Sep 14. The Balinese can be an affectionate and lively kitty for most households, especially if you have children. Effect of chicken egg yolk antibodies (IgY) against diarrhea in domesticated animals: A systematic review and meta-analysis. Ann Allergy. Results: The study included 26 cats, 13 male, 13 female, age 5.6 4.3 years (mean SD). Large scale research has shown that all cats produce some felineallergen (Fel-d1). Members of Siberian Research submitted data from hundreds of adult Siberians. Bastien BC et al. Although, they do enjoy napping in a quiet corner and tend to shy away from large groups. Female cats produce a lower level of Fel d 1 than (unneutered) males,[5] while neutered males produce levels similar to those of females. government site. This cat breed is very affectionate and cuddly. However, Cornish Rex cats typically need more grooming to lessen the oil build-up on their skin. J Venom Anim Toxins Incl Trop Dis. 2016;5. Both intact and spayed females produce similar levels. The details and results of this study were recently published in a peer-reviewed journal.12. They like to be around people and to be included in activities so they are terrific cats for families. Younger Burmese cats are curious and active, and as they get older, they become placid and prefer to watch rather than getting involved in activities. meow@kitnipbox.com. Veterinary Testing Canine DNA Testing Feline DNA Testing Avian DNA Testing Feline Allergy DNA Test (Fel d1 protein) They make the ideal companions and welcome family and friends attention, as well as being great with kids and other pets. 1 INTRODUCTION. In addition, immunotherapy with Fel d 1 peptides containing T-cell epitopes has been tested in clinical trials. Epub 2021 Oct 8. These include Fel d 1 hypoallergens and allergen constructs where Fel d 1 is coupled to immunomodulatory proteins or carriers. The 26 cats studied came to the clinic for procedures that required anesthesia, mainly dentistry and spaying (see. . A minimum of three tests must be perfomed for each cat for the results to be considered reasonably accurate in adult cats. Low-level release of Fel D1 protein and low shedding makes them nearly a hypoallergenic. F1000Res. It is true that Russian Blue cats have lower levels of Fel d 1, the protein in cat saliva and skin secretions responsible for your itching and wheezing. Russian blues are intelligent cats. It was noted that the levels of aFel d1 were lower in chambers loaded with blankets from cats fed the test diet in comparison to those with blankets from cats fed the control diet. Use of the termsVery Low,Low,Medium, andHigh to describe allergen levels are considered part of the copyrights and trademarks of Siberian Research. A kitten from two parents with very, very low allergens will also have a low allergen level. They provide detailed reference charts and more accurate testing methods than were used for these studies. This is why it can be adapted to people who are normally allergic to cats. As a member of the Siamese family, he'll likely be quite talkative. Their markings are distributed across their bodies and each hair on their coat contains more than one colour. In fact, people are twice as likely to have cat allergies than dog allergies. Clark J et al. Due to biological interactions, it not suitable for testing Fel d-1. On average, there was a 47% reduction of active Fel d1 on cats' hair after three weeks of feeding the diet. FEL-D1, produced largely in saliva and sebaceous glands of cats and kittens, is the major allergen responsible for symptoms.In Western countries, the prevalence of cat allergies has increased dramatically to 10-30% in the general population. Here are 17 Cat Breeds that are hypoallergenic relative to others. Approximately 100 mg of each sample was quantitatively analysed for aFel d1 levels using the previously mentioned ELISA kit. Scientific foundations of allergen-specific immunotherapy for allergic disease. Since the intelligent, energetic Balinese produces a little less Fel d 1 and has a single layer coat, he's often a great choice for people with mild cat allergies, even though he's a little fluffy. Symptoms range from mild rhinoconjunctivitis to potentially life-threatening asthmatic exacerbations. Human allergy to cats: A review for veterinarians on prevalence, causes, symptoms and control.
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